Polymorphisms in the Estrogen Receptor β (ESR2) Gene Are Associated with Bone Mineral Density in Caucasian Men and Women
نویسندگان
چکیده
منابع مشابه
Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men.
Although bone mineral density (BMD) is a complex trait that is influenced by both genetic and environmental factors, heritability studies in twins and families have shown that genetic factors account for 60-85% of the variance in BMD. We examined the relations of six candidate gene polymorphisms to BMD in community-dwelling women and men. The 2238 subjects (1110 women, 1128 men) were aged 40-79...
متن کاملPolymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women.
BACKGROUND Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2). METHODS Three polymorphisms of the ESR2 gene, and their associated haplotypes, were evaluated in 296 white women from the Women's Health Study and 566 white me...
متن کاملThe effects of transdermal estrogen delivery on bone mineral density in postmenopausal women: A meta-analysis
Background: Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.The present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal women.Methods: Studies were identified by searching electronic databases including Cochrane Library, MEDLINE, Embase...
متن کاملThe effects of transdermal estrogen delivery on bone mineral density in postmenopausal women: A meta-analysis
Background: Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.The present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal women.Methods: Studies were identified by searching electronic databases including Cochrane Library, MEDLINE, Embase...
متن کاملOriginal Contribution Estrogen Therapy and Bone Mineral Density in African-American and Caucasian Women
Controlling for body size and composition, the authors examined the association between estrogen therapy and bonemineral density in older African-American andCaucasian women. In 1992–1998, 443 African-American and 989 Caucasian women aged 45–87 years were assessed for medication use, laboratory variables, behavioral characteristics, and bone mineral density. The mean age was 61.3 (95% confidenc...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2005
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2004-2253